A Nonlinear Finite Element Model for the Evaluation of Instabilities in Atherosclerotic Plaques
نویسندگان
چکیده
Detection of plaques vulnerable to rupture may reduce the incidence of acute myocardial infarction. Instability of atherosclerotic plaques, defined as the propensity of fibrous caps to burst, has been thought to occur at places where fibrous caps (FC) are thin and necrotic core (NC) areas are large and compliant. However, here we show quantitatively, using a fibre-reinforced, anisotropic, and hyperelastic finite element model, that FC thickness and NC size and compliance alone are limited in predicting vulnerable plaques. We suggest that plaque instabilities primarily occur at sites of stress concentrations irrespective of FC thickness or NC area and compliance.
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